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Randomized controlled trials with a placebo comparator arm/group included in the meta-analysis.

First author, yearStudyParticipants( 2 )AgeDurationIron dose( 3 ) FeSO4 placeboBaseline Hb (g/dL)
(reference)design( 1 ) (mean)(weeks)(mg/day)nGISEs n (%)nGISEs n (%)(FeSO4)
Baykan, 2006 [62]ParallelF27.817.3808219 (23)8616 (19)12.9
Cook, 1990 [63]ParallelF18–482506731 (46)6614 (21)NR
Davis, 2000 [64]ParallelRLS58.612130145 (36)140 (0)14.3
Fouad, 2013 [65]ParallelF35125208 (40)204 (20)NR
Ganzoni, 1974 [66]Cross-overM+F27M, 33F21119049 (54)9019 (21)15.25
Gordeuk, 1987 [67]ParallelF, blood donorsNR11802418 (75)238 (35)12.7
Hallberg, 1966_1 [24]ParallelBlood donorsNRNR22217540 (23)16923 (14)NR
Hallberg, 1966_2 [24]ParallelBlood donorsNRNR22211131 (28)11516 (14)NR
Hallberg, 1966_3 [24]ParallelBlood donorsNRNR18017045 (26)17722 (12)NR
Levy, 1978 [68]Cross-overM+F19–554.320010757 (53)10722 (21)NR
Maghsudlu, 2008 [69]ParallelF, blood donors28.7415018519 (10)1828 (4)13.52
Mirrezaie, 2008 [34]ParallelF, blood donors34.28504917 (35)469 (20)NR
Meier, 2003 [70](4) ParallelPregnancy25.2NR603824 (63)3619 (53)13
Makrides, 2003 [71]ParallelPregnancy28.52020200136 (68)193133 (69)13.1
Pereira, [40]ParallelM+F321130109 (90)104 (40)NR
Sutton, 2004 [41]ParallelHip and knee-replacement706195358 (23)378 (22)10.4
Tuomainen, 1999 [72](5) ParallelM45–6426180153 (20)150 (0)14.53
Vaucher, 2012 [60]ParallelF36.51280 slow-Fe10212 (12)9610 (10)13.5
Yalcin, 2009 [73]ParallelPost-partum27.715.380248 (33)236 (26)13.1
Waldvogel, 2012 [59]ParallelF, blood donors31.8480 slow-Fe7425 (34)718 (11)12.6