How do you know when you are clear of C. diff?

Clostridium difficile, also known as C. difficile or C. diff, is a bacterium that can infect the bowel and cause diarrhoea.

Índice Show

Symptoms of a C. difficile infection
Who's most at risk of C. difficile?
When to get medical advice
Treatment for C. difficile
Looking after yourself at home
How you get C. difficile
How to stop C. difficile spreading
Who's at risk

The infection most commonly affects people who have recently been treated with antibiotics, but can spread easily to others.

C. difficile infections are unpleasant and can sometimes cause serious bowel problems, but they can usually be treated with another course of antibiotics.

This page covers:

Symptoms of a C. difficile infection

Who's most at risk of C. difficile?

When to get medical advice

Treatment for C. difficile

Looking after yourself at home

How you get C. difficile

How to stop C. difficile spreading

Symptoms of a C. difficile infection

Symptoms of a C. difficile infection usually develop when you're taking antibiotics, or when you've finished taking them within the last few weeks.

The most common symptoms are:

watery diarrhoea, which can be bloody
painful tummy cramps
feeling sick
signs of dehydration, such as a dry mouth, headaches and peeing less often than normal
a high temperature (fever) of above 38C (100.4F)
loss of appetite and weight loss

In some cases, serious complications can develop, such as damage to the bowel or severe dehydration, which may cause drowsiness, confusion, a rapid heart rate and fainting.

Who's most at risk of C. difficile?

C. difficile mostly affects people who:

have been treated with broad-spectrum antibiotics (antibiotics that work against several types of bacteria) or several different antibiotics at the same time, or those taking long-term antibiotics
have had to stay in a healthcare setting, such as a hospital or care home, for a long time
are over 65 years old
have certain underlying conditions, including inflammatory bowel disease (IBD), cancer or kidney disease
have a weakened immune system, which can be because of a condition such as diabetes or a side effect of a treatment such as chemotherapy or steroid medication
are taking a medication called a proton pump inhibitor (PPI) to reduce the amount of stomach acid they produce
have had surgery on their digestive system

Many C. difficile infections used to occur in places where many people take antibiotics and are in close contact with each other, such as hospitals and care homes.

However, strict infection control measures have helped to reduce this risk, and an increasing number of C. difficile infections now occur outside these settings.

When to get medical advice

Visiting your GP surgery with a possible C. difficile infection can put others at risk, so it's best to call your GP or NHS 111 if you're concerned or feel you need advice.

Get medical advice if:

you have persistent diarrhoea after finishing a course of antibiotics
you have bloody diarrhoea
you have diarrhoea and experience severe tummy pain, a high fever, a rapid heart rate or fainting
you have symptoms of severe dehydration, such as confusion, drowsiness, only passing small amounts of urine or no urine at all

Diarrhoea can be caused by a number of conditions and is a common side effect of antibiotics, so having diarrhoea while taking antibiotics doesn't necessarily mean you have a C. difficile infection.

Your GP may suggest sending off a sample of your poo to confirm whether you have C. difficile. A blood test may also be carried out to help determine how severe the infection is, and sometimes you may need tests or scans in hospital to check if your bowel is damaged.

Treatment for C. difficile

Your GP will decide whether you need hospital treatment (if you're not already in hospital). If the infection is relatively mild, you may be treated at home.

If you're in hospital, you might be moved to a room of your own during treatment to reduce the risk of the infection spreading to others.

Treatment for C. difficile can include:

stopping the antibiotics thought to be causing the infection, if possible – in mild cases, this may be the only treatment that's needed
taking a 10 to 14-day course of antibiotics that are known to kill C. difficile bacteria
rarely, serious infections may require surgery to remove a damaged section of the bowel

C. difficile infections usually respond well to treatment, with most people making a full recovery in a week or two. However, the symptoms come back in around 1 in 5 cases and treatment may need to be repeated.

Looking after yourself at home

If you're well enough to be treated at home, the following measures can help relieve your symptoms and prevent the infection spreading:

make sure you finish the entire course of any antibiotics you're prescribed, even if you're feeling better
drink plenty of fluids to avoid dehydration and eat plain foods such as soup, rice, pasta and bread if you feel hungry
take paracetamol for tummy pain or a fever
don't take anti-diarrhoeal medication, as this can stop the infection being cleared from your body
regularly wash your hands and contaminated surfaces, objects or sheets (see How to stop C. difficile spreading)
stay at home until at least 48 hours after your last episode of diarrhoea

Your GP may contact you regularly to make sure you're getting better. Call them if your symptoms return after treatment finishes, as it may need to be repeated.

How you get C. difficile

C. difficile bacteria are found in the digestive system of about 1 in every 30 healthy adults. The bacteria often live harmlessly because the other bacteria normally found in the bowel keep it under control.

However, some antibiotics can interfere with the balance of bacteria in the bowel, which can cause the C. difficile bacteria to multiply and produce toxins that make the person ill.

When this happens, C. difficile can spread easily to other people because the bacteria are passed out of the body in the person's diarrhoea.

Once out of the body, the bacteria turn into resistant cells called spores. These can survive for long periods on hands, surfaces (such as toilets), objects and clothing unless they're thoroughly cleaned, and can infect someone else if they get into their mouth.

Someone with a C. difficile infection is generally considered to be infectious until at least 48 hours after their symptoms have cleared up.

How to stop C. difficile spreading

C. difficile infections can be passed on very easily. You can reduce your risk of picking it up or spreading it by practising good hygiene, both at home and in healthcare settings.

The following measures can help:

stay at home until at least 48 hours after your symptoms have cleared up
wash your hands regularly with soap and water, particularly after going to the toilet and before eating – use liquid rather than bar soap and don't use flannels or nail brushes
clean contaminated surfaces – such as the toilet, flush handle, light switches and door handles – with a bleach-based cleaner after each use
don't share towels and flannels
wash contaminated clothes and sheets separately from other washing at the highest possible temperature
when visiting someone in hospital, observe any visiting guidelines, avoid taking any children under the age of 12, and wash your hands with liquid soap and water when entering and leaving ward areas – don't rely on alcohol hand gels, as they're not effective against C. difficile
avoid visiting hospital if you're feeling unwell or have recently had diarrhoea

Clostridium difficile (C. diff) is a type of bacteria that can cause diarrhoea. It often affects people who have been taking antibiotics. It can usually be treated with a different type of antibiotic.

Common symptoms of a C. diff infection include:

diarrhoea
a high temperature
loss of appetite
feeling sick
a stomach ache

C. diff bacteria usually live harmlessly in your bowel along with lots of other types of bacteria.

But sometimes when you take antibiotics, the balance of bacteria in your bowel can change, causing an infection.

When someone has a C. diff infection, it can spread to other people very easily if the bacteria found in the person’s poo get onto objects and surfaces.

Who's at risk

You're more likely to get a C. diff infection if:

you're over 65 years
you're taking, or have recently taken, antibiotics
you're staying in hospital or a care home for a long time
you have a weakened immune system – for example, from having a long-term condition like diabetes or kidney failure, or treatment like chemotherapy
you're taking a proton pump inhibitor (PPI), such as omeprazole, or other medicines that reduce stomach acid
you've had a C. diff infection in the past

you have diarrhoea and you're taking, or have recently taken, antibiotics
you have bloody diarrhoea or bleeding from the bottom
you have diarrhoea for more than 7 days

You can call 111 or get help from 111 online.

If a doctor thinks you have a C. diff infection, they may ask for a sample of your poo to be tested.

The infection can sometimes be treated at home, or you might need to go into hospital. This is because C. diff infections can sometimes lead to more serious problems like sepsis.

A C. diff infection is treated by:

stopping any antibiotics you're taking, if possible
taking a 10-day course of another antibiotic that can treat the C. diff infection

You'll also be given advice about how to avoid dehydration, such as making sure you drink plenty of water.

Your symptoms should improve a few days after starting the new course of antibiotics. But it may be 1 to 2 weeks before the infection clears up completely.

Go back to see the GP if your symptoms get worse, you feel very unwell after starting the antibiotics, or your symptoms come back afterwards.

If your symptoms return, treatment may need to be repeated.

Carry on taking your antibiotics until you've finished all your tablets, capsules or liquid, even if you feel better. If you stop your treatment early, your symptoms could come back.

C. diff infections can spread very easily. There are some things you can do to reduce the risk of passing it on to others.

stay at home until at least 48 hours after your diarrhoea stops
wash your hands regularly using soap and water
clean the toilet and area around it with disinfectant after each use
wash clothes and sheets with poo on separately from other washing at the highest possible temperature

do not share towels and flannels
do not take medicine to stop diarrhoea like loperamide because it can prevent the infection being cleared from your body

Page last reviewed: 08 February 2022
Next review due: 08 February 2025